Tissue Engineering Group
The Tissue Engineering and Nanoporous Materials Group focuses on cross disciplinary applications of engineering involving biological systems, in particular biomaterials, tissue engineering, nanoporous materials and downstream processing for biotechnology.
We have developed techniques for the production of biodegradable polymer constructs including hydrogels, porous scaffolds with tailored morphology for cell growth and microspheres for bioactive molecule delivery. We have expertise in fabrication, surface modification and physicochemical characterisation of biological tissues and biomaterials, encapsulation and release of biomolecules and in vitro testing of biomaterials. Our research involves collaborations with engineers, surgeons, cell biologists and mathematicians and includes both in vitro and in vivo studies of the developed biomaterial constructs.
The group is part of the Particulate Fluids Processing Centre at The University of Melbourne. We have a wide variety of well-established interdisciplinary collaborations with medical researchers, clinicians, hospitals and companies in the medtech sector nationally and internationally.
Key Research Directions
Key directions for our research include:
- development of tailored biomolecule delivery vehicles for tissue engineering and regenerative medicine
- development of tailored biomaterials for 3-D cell culture and stem cell differentiation
- optimising biomaterial construct design for soft tissue engineering
- quantifying the mechanics of soft tissues and exploring the potential of mechanotransduction in their regeneration.
We welcome inquiries from prospective students, PhD students and post-doctoral fellows.Read more
Project case study: Porosity to improve cranial bone implants
A technique to make polymer-based skull implants more bone-like in their structure has been developed to improve outcomes for patients relying on implants to repair cranial injuries.
Assoc Prof Andrea O’Connor