Recent publications

  1. Karas J, Sani M, Separovic F. Chemical Synthesis and Characterization of an Equinatoxin II(1-85) Analogue. MOLECULES. Molecular Diversity Preservation International. 2017, Vol. 22, Issue 4. DOI: 10.3390/molecules22040559
  2. North A, Karas J, Ma MT, Blower PJ, Ackermann U, White J, Donnelly P. Rhenium and Technetium-oxo Complexes with Thioamide Derivatives of Pyridylhydrazine Bifunctional Chelators Conjugated to the Tumour Targeting Peptides Octreotate and Cyclic-RGDfK. INORGANIC CHEMISTRY. American Chemical Society. 2017, Vol. 56, Issue 16. DOI: 10.1021/acs.inorgchem.7b01247
  3. Karas J, Noor A, Schieber C, Connell T, Separovic F, Donnelly P. The efficient synthesis and purification of amyloid-beta(1-42) using an oligoethylene glycol-containing photocleavable lysine tag. CHEMICAL COMMUNICATIONS. Royal Society of Chemistry. 2017, Vol. 53, Issue 51. DOI: 10.1039/c7cc03147e
  4. Li X, Burger S, O'Connor A, Ong L, Karas J, Gras S. An enzyme-responsive controlled release system based on a dual-functional peptide. CHEMICAL COMMUNICATIONS. Royal Society of Chemistry. 2016, Vol. 52, Issue 29. DOI: 10.1039/c5cc10480g
  5. Karas J, Patil N, Tailhades J, Sani M, Scanlon DB, Forbes BE, Gardiner J, Separovic F, Wade J, Hossain M. Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. Wiley-VCH. 2016, Vol. 55, Issue 47. DOI: 10.1002/anie.201607101
  6. Karas J, Scanlon B, Forbes E, Vetter, Lewis JM, Gardiner, Separovic F, Wade J, Hossain MA. 2-Nitroveratryl as a photocleavable thiol protecting group for directed disulfide bond formation in the chemical synthesis of insulin. Chemistry - A European Journal. Wiley-VCH. 2014, Vol. 20. DOI: 10.1002/chem.201403574
  7. Cottam JM, Scanlon DB, Karas J, Calabrese AN, Pukala TL, Forbes BE, Wallace JC, Abell AD. Chemical Synthesis of a Fluorescent IGF-II Analogue. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. Springer Verlag. 2013, Vol. 19, Issue 1. DOI: 10.1007/s10989-012-9339-3
  8. Kok W, Cottam J, Ciccotosto G, Miles L, Karas J, Scanlon D, Roberts B, Parker M, Cappai R, Barnham K, Hutton C. Synthetic dityrosine-linked beta-amyloid dimers form stable, soluble, neurotoxic oligomers. Chemical Science. Royal Society of Chemistry. 2013, Vol. 4, Issue 12. DOI: 10.1039/c3sc22295k
  9. Karas J, Shabanpoor F, Hossain MA, Gardiner, Separovic F, Wade J, Scanlon D. Total Chemical Synthesis of a Heterodimeric Interchain Bis-Lactam-Linked Peptide: Application to an Analogue of Human Insulin-Like Peptide 3. International Journal of Peptides. Hindawi Publishing Corp. 2013, Vol. 2013. DOI: 10.1155/2013/504260
  10. Griffin M, Yeung L, Hung A, Todorova N, Mok Y, Karas J, Gooley P, Yarovsky I, Howlett G. A Cyclic Peptide Inhibitor of ApoC-II Peptide Fibril Formation: Mechanistic Insight from NMR and Molecular Dynamics Analysis. Journal of Molecular Biology. Academic Press. 2012, Vol. 416, Issue 5. DOI: 10.1016/j.jmb.2011.12.059
  11. Karas J, Boland M, Haigh C, Johanssen V, Hill A, Barnham K, Collins S, Scanlon D. Microwave Synthesis of Prion Protein Fragments up to 111 Amino Acids in Length Generates Biologically Active Peptides. International Journal of Peptide Research and Therapeutics. Springer Verlag. 2012, Vol. 18, Issue 1. DOI: 10.1007/s10989-011-9275-7
  12. Safavi-Hemami H, Gorasia D, Steiner AM, Williamson N, Karas J, Gajewiak J, Olivera BM, Bulaj G, Purcell AW. Modulation of Conotoxin Structure and Function Is Achieved through a Multienzyme Complex in the Venom Glands of Cone Snails. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. 2012, Vol. 287, Issue 41. DOI: 10.1074/jbc.M112.366781
  13. Safavi-Hemami H, Siero W, Kuang Z, Williamson N, Karas J, Page L, MacMillan D, Callaghan B, Kompella S, Adams D, Norton R, Purcell A. Embryonic Toxin Expression in the Cone Snail Conus victoriae PRIMED TO KILL OR DIVERGENT FUNCTION?. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. 2011, Vol. 286, Issue 25. DOI: 10.1074/jbc.M110.217703
  14. Ma M, Neels O, Denoyer D, Roselt P, Karas J, Scanlon D, White J, Hicks R, Donnelly P. Gallium-68 Complex of a Macrobicyclic Cage Amine Chelator Tethered to Two Integrin-Targeting Peptides for Diagnostic Tumor Imaging. Bioconjugate Chemistry. American Chemical Society. 2011, Vol. 22, Issue 10. DOI: 10.1021/bc200319q
  15. Ma M, Cooper M, Paul R, Shaw K, Karas J, Scanlon D, White J, Blower P, Donnelly P. Macrobicyclic Cage Amine Ligands for Copper Radiopharmaceuticals: A Single Bivalent Cage Amine Containing Two Lys(3)-bombesin Targeting Peptides. Inorganic Chemistry. American Chemical Society. 2011, Vol. 50, Issue 14. DOI: 10.1021/ic200681s

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